Endocrine Abstracts

Objective: The response of the hypothalamo-pituitary-adrenal axis to stress is mediated mainly through corticotrophin-releasing hormone and vasopressin. Accordingly, vasopressin levels are increased in septic shock. However, measurement of vasopressin is difficult because of its instability and short half-life. Copeptin is a more stable peptide derived from the same precursor molecule. This study aims to evaluate copeptin levels and its prognostic value in a prospective observ...

Background: Copeptin (CP), a derivate from the antidiuretic hormone (ADH) precursor pre-pro-vasopressin, stochiometrically mirrors ADH secretion. CP is increasingly evaluated as a diagnostic and prognostic biomarker in different diseases. It is therefore important to recognize possible confounding factors when interpreting CP levels. In healthy regularly menstruating women, there is a small but measurable physiological variability of hormones involved in fluid regulation. ADH ...

Objective: Neurotensin is an anorexigenic peptide produced mainly in the N-cells of the ileum; levels are decreased in obese subjects and increase after bariatric surgery. This study is the first to compare the baseline and postoperative levels of neurotensin in patients after gastric bypass, gastric banding, and non-operated controls, respectively, during long-term follow-up.Patients and Methods: Overnight fasting plasma neurotensin levels were measured...